Oxycodone and Naloxone Combination: A 12-Week Follow-up in 20 Patients Shows Effective Analgesia Without Opioid-Induced Bowel Dysfunction
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چکیده
منابع مشابه
Oxycodone and Naloxone Combination: A 12-Week Follow-up in 20 Patients Shows Effective Analgesia Without Opioid-Induced Bowel Dysfunction
INTRODUCTION Opioid analgesics are widely regarded to be highly effective but are equally known for their side effects on the bowel. A new combination of the opioid analgesic oxycodone and naloxone has been developed to combat opioid-induced bowel dysfunction (OIBD) whilst still being effective as an analgesic. The aim of this observational study was to assess the analgesic efficacy of this new...
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INTRODUCTION Opioids are needed for postoperative pain in spine surgery patients, but opioid-induced constipation is a harmful adverse event. The aim of this clinical trial was to compare the use of a controlled-release oxycodone-naloxone combination product with oxycodone controlled-release tablets in these patients. The main outcome measure was the prevalence of constipation at 7 days postope...
متن کاملEfficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised, double-blind clinical trials
BACKGROUND Two randomised 12-week, double-blind, parallel-group, multicenter studies comparing oxycodone PR/naloxone PR and oxycodone PR alone on symptoms of opioid-induced bowel dysfunction in patients with moderate/severe non-malignant pain have been conducted. METHODS These studies were prospectively designed to be pooled and the primary outcome measure of the pooled data analysis was to d...
متن کاملOxycodone/naloxone as a therapeutic option in a patient with chronic pain and opioid-induced bowel dysfunction
Cancer-induced pain is a complex issue of utmost importance in everyday clinical practice. Published data show that the majority of patients with advanced or disseminated cancer and between 27% and 60% of ambulatory cancer patients in various stages of the disease may suffer from moderate or severe pain (VAS 5–10) [1, 2]. However, it has been demonstrated that up to 82% of patients with cancer-...
متن کاملLong-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain
OBJECTIVE The aim of this study was to assess safety and efficacy of fixed combination oxycodone prolonged release (PR)/naloxone PR in terms of both analgesia and improving opioid-induced bowel dysfunction (OIBD) and associated symptoms, such as opioid-induced constipation (OIC), in adults with chronic non-cancer pain. STUDY DESIGN These were open-label extension studies in which patients who...
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ژورنال
عنوان ژورنال: Pain and Therapy
سال: 2016
ISSN: 2193-8237,2193-651X
DOI: 10.1007/s40122-016-0051-4